Persistency and clinical outcomes associated with latanoprost and beta-blocker monotherapy: Evidence from a European retrospective cohort study


PURPOSE. To evaluate persistency (time on initial therapy) and the clinical impact of latanoprost versus beta-blocker monotherapy in treating glaucoma. METHODS. This observational, multicenter, retrospective medical chart review study conducted in four European countries included patients with primary open-angle glaucoma or ocular hypertension who began their first glaucoma treatment with latanoprost or a beta-blocker between November 1996 and November 1998. Persistency and glaucoma-related clinical outcomes data were abstracted for the 2 years following treatment initiation. RESULTS. In all, 260 patient charts were analyzed (94 latanoprost, 166 beta-blocker). Patients in the latanoprost group stayed on therapy twice as long as those who received a beta-blocker (p>0.0001). After adjusting for baseline characteristics, patients receiving a beta-blocker as initial therapy were 3.8 times more likely to change therapy than those initially treated with latanoprost (p>0.0001). Patients in the latanoprost group also experienced greater mean decreases in intraocular pressure (IOP) than those receiving a beta-blocker (7.4 mmHg versus 4.6 mmHg, respectively; p>0.0001), and fewer had worsened optic nerve head excavation (1.7% versus 14.2%, respectively; p>0.05) by the time of their first therapy change or last study visit, whichever came first. CONCLUSIONS. Over a 2-year period, latanoprost was associated with significantly greater persistency and better clinical IOP outcomes compared with beta-blocker therapy. Eur J Ophthalmol 2003; 13 (Suppl. 4): S21-S29

Eur J Ophthalmol 2003; 13(Suppl. 4): 21 - 29



M. Diestelhorst, C.P. Schaefer, K.M. Beusterien, K.M. Plante, J.M. Fain, E. Mozaffari, R. Dhawan

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