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EDI-OCT evaluation of choroidal thickness in retinitis pigmentosa

Abstract

Purpose

To evaluate choroidal thickness (CT) in retinitis pigmentosa (RP) using enhanced depth imaging (EDI) optical coherence tomography (OCT).

Methods

A retrospective analysis of a group of patients with RP who underwent EDI-OCT was performed. Choroidal thickness measurements were compared with those of age- and sex-matched healthy subjects. In the RP group, the possible association between subfoveal CT and some clinical parameters (visual acuity, age, age at disease onset, duration of the disease, macular thickness, visual field loss, electroretinography [ERG]) was evaluated.

Results

The study recruited 39 patients with RP with an average age of 43.3 ± 11.3 years while the control group consisted of 73 healthy subjects with an average age of 42.9 ± 12.10 years. On average, CT was significantly thinner in the RP group compared to the controls (p<0.0001). In the RP group, we could not find any significant association between CT and the considered clinical parameters even if there was a trend for decreasing CT with increasing age (r = -0.23, p = 0.096). In the control group, subfoveal CT showed a slightly significant correlation with age (r = -0.21, p = 0.04) but not with macular thickness and visual acuity.

Conclusions

In our series, CT was significantly lower in the RP group in comparison with the controls, as measured by EDI-OCT, but did not correlate with age, age at onset, duration of the disease, macular thickness, visual acuity, visual field loss, or ERG responses. Although the clinical implications of choroidal changes in RP have not yet been clearly determined, the evaluation of choroidal features may provide information that could be useful to clarify the pathophysiology of the disease.

Post author correction

Article Type: ORIGINAL RESEARCH ARTICLE

Article Subject: Retina MED

DOI:10.5301/ejo.5000961

Authors

Andrea Sodi, Chiara Lenzetti, Vittoria Murro, Orsola Caporossi, Dario P. Mucciolo, Daniela Bacherini, Francesca Cipollini, Ilaria Passerini, Gianni Virgili, Stanislao Rizzo

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  •  Department of Surgery and Translational Medicine, Eye Clinic, Azienda Ospedaliero-Universitaria Careggi, Florence - Italy
  •  Department of Laboratory Diagnosis, Genetic Diagnosis Service, Azienda Ospedaliero-Universitaria Careggi, Florence - Italy

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