Effect of pharmacologic pupil dilation on OLCR optical biometry measurements for IOL predictions


Purpose: To determine the possible influence of pupil dilation on intraocular lens (IOL) power predictions made using optical biometry with Lenstar LS 900® (Haag-Streit AG, Koeniz, Switzerland).

Methods: A total of 72 eyes of 72 patients scheduled to undergo cataract surgery were prospectively examined using the optical low-coherence reflectometry (OLCR) optical biometer before and after pupil dilation with tropicamide 1%. The measurements made were axial length, central corneal thickness, anterior chamber depth (ACD), lens thickness, mean keratometry, corneal diameter (CD), and pupil diameter. Holladay II and SRK/T formulas were used to calculate IOL power. Agreement between the 2 measurement modes (with and without dilation) was assessed by calculating intraclass correlation coefficients (ICC) and constructing Bland-Altman plots.

Results: The mean age of the patients was 74.71 ± 7.53 years (range 56-90). Among the variables determined, only ACD varied significantly according to pupil dilation (p<0.001). The ICC data revealed excellent intraobserver correlation between measurements made with and without dilation, except for CD. The IOL power predictions were unmodified.

Conclusions: The use of pupil dilation does not seem to influence measurements and IOL predictions made using this OLCR optical biometer.

Eur J Ophthalmol 2014; 24(1): 53 - 57


Article Subject: Lens/Cataract



Pedro Arriola-Villalobos, David DÍaz-Valle, Nuria Garzo´n, Jorge Ruiz-Medrano, Cristina Fernández-Pe´rez, Nicolás Alejandre-Alba, Julián GarcÍa-Feijoo´

Article History


Financial Support: No financial support was received for this submission.
Conflict of Interest Statement: None of the authors has conflict of interest with this submission.

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  • Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigaci.n Sanitaria del Hospital San Carlos (IdISSC), Madrid - Spain
  • Departamento de Oftalmología y ORL, Facultad de Medicina, Ophthalmology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid - Spain
  • Instituto de Oftalmología Avanzada, Madrid - Spain
  • Research Support Unit, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid - Spain
  • Ophthalmology, Fundación Jiménez Díaz, Madrid - Spain
  • Instituto de Salud Carlos III (Proyecto RD 07/0062: Patología ocular del envejecimiento, calidad visual y calidad de vida), Madrid - Spain

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