Dry eye in Graves ophthalmopathy: correlation with corneal hypoesthesia

Eur J Ophthalmol 2013; 23(4): 473 - 479

Article Type: ORIGINAL ARTICLE

DOI:10.5301/ejo.5000259

Authors

Vasilis Achtsidis, Nicholas Tentolouris, Sofia Theodoropoulou, Dimitris Panagiotidis, Emmanuel Vaikoussis, Manuel Saldana, Pieter Gouws, Panagiotis G. Theodossiadis

Abstract

Purpose. To evaluate dry eye disease and corneal sensitivity in patients with early and active Graves ophthalmopathy (GO).
Methods. A total of 52 eyes of 26 patients with early GO and 74 eyes of 37 age- and sex-matched controls were included in our study. Dry eye disease was assessed based on the criteria of the 
International Dry Eye Workshop. Diagnosis of early GO was based on the European Group on Graves’ Orbitopathy consensus statement. Clinical Activity Score (CAS) and Werner-NOSPECS Score were determined. Corneal sensitivity was assessed using a Cochet-Bonnet aesthesiometer. 
Results. A total of 67.8% of patients with early GO and 13.5% of healthy controls had ocular surface dryness (p<0.001). The mean Schirmer test score was significantly lower in patients with early GO (12.88 ± 7.94 mm [right eyes] and 14.04 ± 9.00 mm [left eyes]) than in controls (18.08 ± 7.26 mm [right eyes] and 18.05 ± 7.50 mm [left eyes] [p<0.05]). The tear film break-up time was lower in patients by 5.46 seconds and 5.74 seconds in right and left eyes (p<0.001). We also found a significant reduction in corneal sensitivity in patients with early GO (4.16 ± 0.68 [right eyes] and 4.10 ± 0.89 [left eyes]) than in controls (4.70 ± 0.34 [right eyes] and 4.72 ± 0.34 [left eyes] [p<0.05]). The CAS correlated significantly with the Schirmer test (r = −0.60, p = 0.003).
Conclusion. Dry eye is common in early GO even in the absence of apparent exophthalmos and is 
associated with CAS and reduced corneal sensitivity.

Article History

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • If you are not a Subscriber you may:
  • Subscribe to this journal

    Unlimited access to all our archives, 24 hour a day, every day of the week.

    Article price: Eur 36.00

    You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.

  • Claim online access

    If you hold a Society membership and you have never accessed the website claim online access to receive your log in credentials

This article has supplementary materials available to download.

  • If you are a Subscriber, please log in now.

  • If you are not a Subscriber you may:
  • Subscribe to this journal

    Unlimited access to all our archives, 24 hour a day, every day of the week.

    Article price: Eur 36.00

    You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.

  • Claim online access

    If you hold a Society membership and you have never accessed the website claim online access to receive your log in credentials

Authors

  • Achtsidis, Vasilis [PubMed] [Google Scholar]
    2nd Department of Ophthalmology, “Attikon” University Hospital, University of Athens, Athens - Greece and Department of Ophthalmology, Conquest Hospital, St. Leonards on Sea, East Sussex - UK
  • Tentolouris, Nicholas [PubMed] [Google Scholar]
    1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, Athens - Greece
  • Theodoropoulou, Sofia [PubMed] [Google Scholar]
    2nd Department of Ophthalmology, “Attikon” University Hospital, University of Athens, Athens - Greece
  • Panagiotidis, Dimitris [PubMed] [Google Scholar]
    2nd Department of Ophthalmology, “Attikon” University Hospital, University of Athens, Athens - Greece
  • Vaikoussis, Emmanuel [PubMed] [Google Scholar]
    Department of Ophthalmology, “St. Panteleimon” General Hospital of Nikaia, Piraeus - Greece
  • Saldana, Manuel [PubMed] [Google Scholar]
    Department of Ophthalmology, Conquest Hospital, St. Leonards on Sea, East Sussex - UK
  • Gouws, Pieter [PubMed] [Google Scholar]
    Department of Ophthalmology, Conquest Hospital, St. Leonards on Sea, East Sussex - UK
  • Theodossiadis, Panagiotis G. [PubMed] [Google Scholar]
    2nd Department of Ophthalmology, “Attikon” University Hospital, University of Athens, Athens - Greece

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.