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Rapid response to dexamethasone intravitreal implant in diabetic macular edema

Abstract

Purpose

To evaluate the early effects of dexamethasone (DEX) intravitreal implants in patients with diabetic macular edema (DME).

Methods

This was a prospective, single-arm, interventional clinical series. Eighteen patients (18 eyes) with chronic/recalcitrant or naive DME were included. Patients underwent single DEX intravitreal implant. Clinical assessments, including ophthalmologic examination, central retinal thickness (CRT) measurement by spectral-domain optical coherence tomography (SD-OCT) scan, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) were carried out at baseline, 1-3 hours, and then 3, 7, and 30 days after treatment. The main outcome was change in CRT on SD-OCT, while secondary outcome measures included visual acuity (VA) and changes in IOP following implant.

Results

Mean CRT significantly decreased from 565 ± 171 µm at baseline to 310 ± 89 µm at end of follow-up (p<0.001), with reduction becoming evident 1-3 hours after injection. Mean BCVA also significantly improved 7 days and 30 days after treatment up to 0.14 logMAR (p<0.05). All patients had a controlled IOP after the injection with only 1/18 eyes having a transient increase in IOP during follow-up.

Conclusions

This is the first study showing very early effects of DEX implants on CRT reduction and VA improvement in DME.

Post author correction

Article Type: ORIGINAL RESEARCH ARTICLE

Article Subject: Retina MED

DOI:10.5301/ejo.5000989

Authors

Giuseppe Lo Giudice, Antonio Avarello, Gianluca Campana, Alessandro Galan

Article History

Disclosures

Financial support: Editorial assistance provided by HPS was supported by an unrestricted grant from Allergan.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • San Paolo Ophthalmic Center, San Antonio Hospital, Padua - Italy
  • Department of General Psychology, University of Padua, Padua - Italy
  • Human Inspired Technology Research Center, University of Padua, Padua - Italy

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