To evaluate the early effects of dexamethasone (DEX) intravitreal implants in patients with diabetic macular edema (DME).
This was a prospective, single-arm, interventional clinical series. Eighteen patients (18 eyes) with chronic/recalcitrant or naive DME were included. Patients underwent single DEX intravitreal implant. Clinical assessments, including ophthalmologic examination, central retinal thickness (CRT) measurement by spectral-domain optical coherence tomography (SD-OCT) scan, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) were carried out at baseline, 1-3 hours, and then 3, 7, and 30 days after treatment. The main outcome was change in CRT on SD-OCT, while secondary outcome measures included visual acuity (VA) and changes in IOP following implant.
Mean CRT significantly decreased from 565 ± 171 µm at baseline to 310 ± 89 µm at end of follow-up (p<0.001), with reduction becoming evident 1-3 hours after injection. Mean BCVA also significantly improved 7 days and 30 days after treatment up to 0.14 logMAR (p<0.05). All patients had a controlled IOP after the injection with only 1/18 eyes having a transient increase in IOP during follow-up.
This is the first study showing very early effects of DEX implants on CRT reduction and VA improvement in DME.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
Article Subject: Retina MED
AuthorsGiuseppe Lo Giudice, Antonio Avarello, Gianluca Campana, Alessandro Galan
- • Accepted on 09/05/2017
- • Available online on 01/07/2017
This article is available as full text PDF.
- Lo Giudice, Giuseppe [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Avarello, Antonio [PubMed] [Google Scholar] 1
- Campana, Gianluca [PubMed] [Google Scholar] 2, 3
- Galan, Alessandro [PubMed] [Google Scholar] 1
San Paolo Ophthalmic Center, San Antonio Hospital, Padua - Italy
Department of General Psychology, University of Padua, Padua - Italy
Human Inspired Technology Research Center, University of Padua, Padua - Italy