Advertisement

Changes in anterior segment morphology 
after intravitreal injection of bevacizumab and 
bevacizumab–triamcinolone acetate combination

Abstract

Purpose: To evaluate the effects of 2 different amounts of commonly used intravitreal agents on anterior segment morphology in conjunction with intraocular pressure (IOP) changes.
Methods: Two groups of 46 patients who received intravitreal injection of bevacizumab (group 1, 
0.05 mL) or bevacizumab–triamcinolone acetate (TA) combination (group 2, 0.1 mL) were included in this prospective study. All patients underwent anterior segment optical coherence tomography 
(AS-OCT) imaging with Visante OCT and IOP measurement before and at 5 minutes, 1 hour, and 
3 hours after injection. Anterior chamber depth (ACD), angle-opening distance (AOD 500-750), trabecular–iris space area (TISA 500-750), and anterior chamber angle (ACA) were measured. Results were compared between groups and measurement time points.
Results: The mean change in IOP showed significant difference between baseline and first measurements after the injection in group 1 and group 2 (p = 0.012, p = 0.008, respectively). There was a statistically significant difference from baseline in ACD at the first and second measurements in group 2 (p = 0.005, p = 0.018, respectively). All angle parameters showed insignificant decrease from baseline at all measurement time points in both groups (p>0.05 for each). The difference 
of angle parameters after injection was not statistically significant between the groups (p>0.05 
for each).
Conclusion: Intravitreal injection of bevacizumab (0.05 mL) or bevacizumab-TA combination (0.1 mL) caused a change in anterior segment configuration determined by AS-OCT. The changes in anterior chamber parameters returned to baseline values with the normalization of IOP values after the first few minutes of injection.

Eur J Ophthalmol 2013; 23(4): 504 - 509

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ejo.5000241

Authors

Zeynep Alkin, Irfan Perente, Cigdem Altan, Aristeidis Konstantinidis, Abdullah Ozkaya, Kemal Yuksel, Ahmet Taylan Yazici, Ahmet Demirok

Article History

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.