To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a nonmydriatic fundus camera, confocal laser scanning ophthalmoscopy (HRT3), and spectral-domain optical coherence tomography (SD-OCT) in uveitic glaucoma.
A total of 59 patients with uveitic glaucoma (21 female, 38 male; mean age 56.8 ± 18.7 years) were included in this prospective cross-sectional study. All patients were measured by the Kowa Nonmyd WX 3D camera (2D/3D nonmydriatic retinal camera, Kowa Company), the HRT3 (Heidelberg Engineering), and SD-OCT (Carl Zeiss Meditec) by one examiner on the same day. All 3 devices graded the optic disc topography. Statistical data were calculated using SPSS (v 20.0, SPSS).
In patients showing borderline results in one of the modalities (n = 45), the DDLS showed a significant correlation with the retinal nerve fiber layer (p = 0.016), while Moorfields regression analysis (p = 0.550) and glaucoma probability score (p = 0.629) did not correlate significantly. The highest predictive power was demonstrated by the objectively measured DDLS (area under the receiver operating characteristic curve 0.445-0.588), compared to R. Burk (0.149-0.375) and F.S. Mikelberg (0.033-0.450) coefficients considering HRT and optical coherence tomography.
In this study cohort, the objective DDLS showed the highest predictive power and thus is a reliable tool in diagnosing uveitic glaucoma. These 3 devices cannot be used interchangeably. As diagnosis and follow-ups are challenging in uveitis patients, the stereophotography is additionally a valuable tool.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
Article Subject: Glaucoma
AuthorsMilena Pahlitzsch, Matthias K.J. Klamann, Saskia Jacob, Carl Erb, Sibylle Winterhalter, Necip Torun, Anna-Karina B. Maier, Eckart Bertelmann
- • Accepted on 17/10/2017
- • Available online on 04/11/2017
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- Pahlitzsch, Milena [PubMed] [Google Scholar] 1, 2, * Corresponding Author (email@example.com)
- Klamann, Matthias K.J. [PubMed] [Google Scholar] 1
- Jacob, Saskia [PubMed] [Google Scholar] 1
- Erb, Carl [PubMed] [Google Scholar] 3
- Winterhalter, Sibylle [PubMed] [Google Scholar] 1
- Torun, Necip [PubMed] [Google Scholar] 1
- Maier, Anna-Karina B. [PubMed] [Google Scholar] 1
- Bertelmann, Eckart [PubMed] [Google Scholar] 1
Department of Ophthalmology, Campus Virchow Clinic, Charité University Medicine, Berlin - Germany
Institute of Ophthalmology, University College London (UCL), London - UK
Department of Ophthalmology, Eye Clinic Wittenbergplatz, Berlin - Germany