To evaluate the association between subfoveal choroidal thickness and the visual outcome in eyes with type 1 choroidal neovascularization (CNV) due to neovascular age-related macular degeneration (nAMD).
This was a retrospective, longitudinal, cross-sectional study including patients diagnosed with nAMD type 1 lesions managed with intravitreal injections of ranibizumab in a PRN strategy during 24 months. Retrospective chart review of patients with type 1 CNV recording the visual acuity, number of intravitreal injections, multimodal imaging data, and follow-up period was performed. Subfoveal choroidal thickness was measured using enhanced depth imaging scans obtained with spectral-domain optical coherence tomography.
Twenty-five eyes of 21 patients were included. The mean baseline logMAR best-corrected visual acuity was 0.52 (+0.35) (median 0.5; range 0.1-1; interquartile range (IQR) 0.3-0.8) and improved to 0.39 (+0.39) (median 0.4; range 0.1-1; IQR 0.2-0.5) by the end of the follow-up (p = 0.038). Subfoveal choroidal thickness was 202.8 (+60.3) μm (median 218; range 81-285; IQR 146-258). Statistical mixed effects model demonstrated an association between rate of improvement of visual acuity with subfoveal choroidal thickness after 24 months (p<0.001) (95% confidence interval 0.0002-0.0001 logMAR month μm); higher thickness values were correlated with better visual acuity.
Thicker subfoveal choroid was associated with better visual outcomes in patients with type 1 CNV due to nAMD following a strict PRN regimen with intravitreal ranibizumab at 24 months of follow-up.
Eur J Ophthalmol 2017; 27(2): 196 - 200
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsPablo Hernández-Martínez, Rosa Dolz-Marco, David Hervás-Marín, Maria Andreu-Fenoll, Roberto Gallego-Pinazo, José Fernando Arévalo
- • Accepted on 01/08/2016
- • Available online on 17/09/2016
- • Published in print on 10/03/2017
This article is available as full text PDF.
- Hernández-Martínez, Pablo [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Dolz-Marco, Rosa [PubMed] [Google Scholar] 1, 2
- Hervás-Marín, David [PubMed] [Google Scholar] 3
- Andreu-Fenoll, Maria [PubMed] [Google Scholar] 1, 2
- Gallego-Pinazo, Roberto [PubMed] [Google Scholar] 1, 2
- Arévalo, José Fernando [PubMed] [Google Scholar] 4
Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia - Spain
RETICS Oftared, Instituto de Salud Carlos III, Madrid - Spain
Biostatistics Unit, Health Research Institute La Fe, Valencia - Spain
Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD - USA