Utility of Bruch membrane opening-based optic nerve head parameters in myopic subjects



To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia.


In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software. With GPME, we analyzed the neuroretinal rim (Bruch membrane opening-minimum rim width [BMO-MRW]) and RNFL.


The average age of subjects was 30.2 ± 9.3 years for G0 and 29.9 ± 7.1 years for G1 (p = 0.903). Mean sphere was -0.5 ± 0.3 D (-1.25 to 0 D) G0 and -3.9 ± 0.3 D (-6.00 to -3 D) G1 (p<0.001). The RNFL thickness comparison between G0 and G1 showed a significantly lower thickness in G1 (p = 0.018). The BMO-MRW measurements were similar in both groups (p = 0.331). With the BMO-MRW examination, the number of sectors classified as pathologic per subject in G1 were significantly lower compared to RNFL analysis (p = 0.023).


Ring analysis based on BMO-MRW measurements shows a lower rate of false-positives compared to RNFL thickness when studying healthy moderate myopic eyes and it would be advisable to take this into consideration when analyzing these patients.

Post author correction


Article Subject: Glaucoma



Marina Sastre-Ibañez, Jose M. Martinez-de-la-Casa, Gema Rebolleda, Pilar Cifuentes-Canorea, Maria Nieves-Moreno, Laura Morales-Fernandez, Federico Saenz-Frances, Julian Garcia-Feijoo

Article History


Financial support: Instituto de Salud Carlos III, Red Temática de Investigación Cooperativa, OFTARED, Enfermedades oculares: Prevención, deteccion precoz y tratamiento de la patología ocular prevalente degenrativa y crónica; and Grupo de Investigación de la Universidad Complutense de Madrid 920415-GR58/0.
Conflict of interest: None of the authors has conflict of interest with this submission.

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  •  Department of Ophthalmolgy, San Carlos Clinical Hospital, Madrid - Spain
  •  Department of Ophthalmology, Faculty of Medicine, Complutense University of Madrid, Madrid - Spain
  •  Health Research Institute of the San Carlos Clinical Hospital (IdISSC), Madrid - Spain
  •  Department of Ophthalmolgy, Ramón y Cajal Hospital, Madrid - Spain

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