To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects.
Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions.
The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm2 and 0.270 ± 0.090 mm2, respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the first and second observers, respectively. The coefficient of repeatability average measurements of FAZ area were 0.021 mm2 and 0.024 mm2. The intraclass correlation coefficient values were 0.993 (95% CI 0.989 to 0.996) and 0.991 (95% CI 0.986 to 0.995). Interobserver and intraobserver concordance correlation coefficients ranged from 0.998 (95% CI 0.997 to 0.999) to 0.999 (95% CI 0.998 to 0.999) and from 0.989 (95% CI 0.982 to 0.993) to 0.987 (95% CI 0.979 to 0.992), respectively.
The FAZ area measurements by means of SS-OCTA showed high reproducibility and repeatability in healthy eyes.
Eur J Ophthalmol 2017; 27(3): 336 - 341
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsRodolfo Mastropasqua, Lisa Toto, Peter A. Mattei, Marta Di Nicola, Isaia A.L. Zecca, Paolo Carpineto, Luca Di Antonio
- • Accepted on 27/07/2016
- • Available online on 09/09/2016
- • Published in print on 11/05/2017
This article is available as full text PDF.
- Mastropasqua, Rodolfo [PubMed] [Google Scholar] 1
- Toto, Lisa [PubMed] [Google Scholar] 2, * Corresponding Author (firstname.lastname@example.org)
- Mattei, Peter A. [PubMed] [Google Scholar] 2
- Di Nicola, Marta [PubMed] [Google Scholar] 3
- Zecca, Isaia A.L. [PubMed] [Google Scholar] 3
- Carpineto, Paolo [PubMed] [Google Scholar] 2
- Di Antonio, Luca [PubMed] [Google Scholar] 2
Ophthalmology Clinic, Moorfields Eye Hospital, London - UK
Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University “G. d’Annunzio” Chieti-Pescara, Chieti - Italy
Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University “G. d’Annunzio” Chieti-Pescara, Chieti - Italy
Rodolfo Mastropasqua and Lisa Toto contributed equally to the manuscript and should be considered as co-first authors.