Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects



To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects.


Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions.


The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm2 and 0.270 ± 0.090 mm2, respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the first and second observers, respectively. The coefficient of repeatability average measurements of FAZ area were 0.021 mm2 and 0.024 mm2. The intraclass correlation coefficient values were 0.993 (95% CI 0.989 to 0.996) and 0.991 (95% CI 0.986 to 0.995). Interobserver and intraobserver concordance correlation coefficients ranged from 0.998 (95% CI 0.997 to 0.999) to 0.999 (95% CI 0.998 to 0.999) and from 0.989 (95% CI 0.982 to 0.993) to 0.987 (95% CI 0.979 to 0.992), respectively.


The FAZ area measurements by means of SS-OCTA showed high reproducibility and repeatability in healthy eyes.

Eur J Ophthalmol 2017; 27(3): 336 - 341




Rodolfo Mastropasqua, Lisa Toto, Peter A. Mattei, Marta Di Nicola, Isaia A.L. Zecca, Paolo Carpineto, Luca Di Antonio

Article History


Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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  • Ophthalmology Clinic, Moorfields Eye Hospital, London - UK
  • Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University “G. d’Annunzio” Chieti-Pescara, Chieti - Italy
  • Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University “G. d’Annunzio” Chieti-Pescara, Chieti - Italy
  • Rodolfo Mastropasqua and Lisa Toto contributed equally to the manuscript and should be considered as co-first authors.

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