Optical coherence tomography imaging in the management of the Argus II retinal prosthesis system



To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management.


This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol. Complete screening procedures had involved 66 eyes of 33 patients afferent to the Center for Retinitis Pigmentosa of the Veneto Region.


Preoperative OCT examination resulted in the exclusion of 8 eyes in 4 patients with bilateral posterior staphyloma diagnosing unexpected staphylomatous macular patterns in 2 patients with RP and no sign of pathologic myopia. Postoperative OCT study of Argus II proximity to retinal surface indicated a plausible correlation between electrode–retina distance and perceptual threshold in 2 of our 3 patients. In particular, during the first 6 months of follow-up, the patient with the closest contact between device and macula showed a continuous vision-related improvement in the performance of several real-life tasks.


The present findings illustrate the modalities by which each different OCT examination is an essential tool to optimize safety and efficacy profiles during Argus II protocol. Optical coherence tomography will be crucial for future investigative approaches on patient selection criteria and next-generation implant design.

Eur J Ophthalmol 2017; 27(1): e16 - e21

Article Type: CASE REPORT



Francesco Parmeggiani, Katia De Nadai, Angela Piovan, Andrea Binotto, Sara Zamengo, Marzio Chizzolini

Article History


Financial support: Supported by grants from the Healthcare Research Project Fund of the Veneto Region (RSFR 330/2010; DGRV Resolution no. 1000/2012) and from the Rehabilitation Project Fund of the Veneto Region (Argus II PM-01-01; DGRV Resolution no. 2314/2014).
Conflict of interest: None of the authors has conflict of interest with this submission.

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  • Eye Clinic, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara - Italy
  • Center for Retinitis Pigmentosa of Veneto Region, ULSS 15 Alta Padovana, Camposampiero, Padova - Italy

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