Posterior capsule opacification 9 years after phacoemulsification with a hydrophobic and a hydrophilic intraocular lens



To compare the development of posterior capsule opacification (PCO) and survival rate without capsulotomy after implantation of a hydrophobic or hydrophilic acrylic intraocular lens (IOL) at the 9-year postoperative follow-up.


One of 3 experienced cataract surgeons performed standard phacoemulsification in one eye of 120 patients with cataract. The patients were randomized to implantation of either a hydrophobic acrylic IOL or a hydrophilic acrylic IOL. Both IOLs had sharp posterior edges. Retroillumination images of PCO were obtained with a fundus camera 9 years postoperatively and analyzed semiobjectively using POCOman computer software.


Seventy-eight of the 120 patients completed the 9-year follow-up examination. Patients implanted with the hydrophilic IOL had significantly (p<0.001) more and denser PCO. The survival rate without Nd:YAG capsulotomy was significantly higher (p<0.001) in eyes with the hydrophobic IOL.


After 9 years, more and denser PCO developed in eyes with the hydrophilic IOL than the hydrophobic IOL. The survival rate without the need for capsulotomy was higher in eyes with the hydrophobic IOL.

Eur J Ophthalmol 2017; 27(2): 164 - 168




Anthony Chang, Maria Kugelberg

Article History


Financial support: Financial support was provided through a regional agreement on medical training and clinical research between the Stockholm County Council and the Karolinska Institutet, Stockholm. The study was also supported by grants from Ögonfonden. The funding organizations had no role in the design or conduct of this research.
Conflict of interest: None of the authors has conflict of interest with this submission.

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  • St. Erik Eye Hospital, Karolinska Institutet, Stockholm - Sweden

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