To determine the effect of intravenous mannitol on globe and orbital volumes.
Retrospective chart review of a consecutive series of Cleveland Clinic Neurosurgical Intensive Care Unit patients who underwent computed tomographic imaging before and after intravenous mannitol administration. Volume measurements were performed according to a previously described technique by averaging axial image areas. Measurements before and after mannitol administration were compared using paired t-test.
Fourteen patients (28 eyes) met inclusion criteria. Average globe volume decreased 186 mm3 (-2.5%, p = 0.02) after mannitol administration, while average orbital volume increased 353 mm3 (+3.5%, p = 0.04). Average globe volume change for subjects with follow-up scan less than 4.7 hours (mean 1.9 hours; range 0.2-4.5 hours) after mannitol administration was -125 mm3 (-1.7%, p = 0.24) and average orbital volume change was +458 mm3 (+5.1%, p = 0.11). Average globe volume change after mannitol administration for those with follow-up more than 4.7 hours (average 13.9 hours, range 4.9-24.7 hours) was -246 mm3 (-3.3%, p = 0.05) and orbital volume change was +248 mm3 (+2.2%, p = 0.24). Dividing the study population into groups based on mannitol dose did not yield any statistically significant change.
Human globe volume decreases after intravenous mannitol administration, while orbital volume increases. These volume changes occur during the time period when intraocular pressure normalizes, after the pressure-lowering effects of the drug. This novel volumetric information improves our understanding of mannitol’s mechanism of action and its effects on human ocular and periocular tissues.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
Article Subject: Orbital disease
AuthorsAdam C. Weber, Alexander D. Blandford, Bryan R. Costin, Julian D. Perry
- • Accepted on 20/06/2017
- • Available online on 02/08/2017
This article is available as full text PDF.
- Weber, Adam C. [PubMed] [Google Scholar] 1
- Blandford, Alexander D. [PubMed] [Google Scholar] 2
- Costin, Bryan R. [PubMed] [Google Scholar] 2
- Perry, Julian D. [PubMed] [Google Scholar] 2, * Corresponding Author (firstname.lastname@example.org)
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas - USA
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio - USA