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Palladium-103 plaque radiation therapy for ciliary body melanoma through a functioning glaucoma filtering bleb

Abstract

Purpose

To provide a clinical description of the long-term outcome of a 103Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb.

Methods

A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a 103Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. At plaque insertion, amniotic membrane grafts were used to cover the plaque and protect the filtering site.

Results

The tumor was successfully treated without clinical evidence of harm to the filtering bleb, with resultant stable intraocular pressure. However, the patient developed blebitis 1.5 years later. Though it resolved with topical antibiotic therapy, the bleb became less succulent. Two years postoperatively, she developed a spontaneous hyphema that resolved after one injection of transscleral bevacizumab 1.25 mg. Her tumor continually regressed in thickness. Without additional glaucoma surgery, her intraocular pressure remained well-controlled on topical medications for 6 years.

Conclusions

Ciliary body melanoma with minimal extrascleral extension beneath a functioning filtering bleb can be treated using radioactive plaque therapy. In this case, we were able to achieve both tumor regression and glaucoma control by covering the plaque with an amniotic membrane graft.

Post author correction

Article Type: CASE REPORT

Article Subject: Tumors

DOI:10.5301/ejo.5001046

Authors

Arif H.K. Pathan, Alexander Barash, Lawrence B. Tena, Paul T. Finger

Article History

Disclosures

Financial support: Supported by The Eye Cancer Foundation (eyecancercure.com) and an International Council of Ophthalmology Fellowship awarded to Dr. Arif H.K. Pathan.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • Department of Ophthalmology, Ocular Tumor Service, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York - USA
  • Departments of Ophthalmic and Radiation Oncology, The New York Eye Cancer Center, New York, New York - USA
  • Departments of Ophthalmology and Radiation Oncology, Mount Sinai Icahn School of Medicine, New York, New York - USA

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