To provide a clinical description of the long-term outcome of a 103Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb.
A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a 103Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. At plaque insertion, amniotic membrane grafts were used to cover the plaque and protect the filtering site.
The tumor was successfully treated without clinical evidence of harm to the filtering bleb, with resultant stable intraocular pressure. However, the patient developed blebitis 1.5 years later. Though it resolved with topical antibiotic therapy, the bleb became less succulent. Two years postoperatively, she developed a spontaneous hyphema that resolved after one injection of transscleral bevacizumab 1.25 mg. Her tumor continually regressed in thickness. Without additional glaucoma surgery, her intraocular pressure remained well-controlled on topical medications for 6 years.
Ciliary body melanoma with minimal extrascleral extension beneath a functioning filtering bleb can be treated using radioactive plaque therapy. In this case, we were able to achieve both tumor regression and glaucoma control by covering the plaque with an amniotic membrane graft.
Post author correction
Article Type: CASE REPORT
Article Subject: Tumors
AuthorsArif H.K. Pathan, Alexander Barash, Lawrence B. Tena, Paul T. Finger
- • Accepted on 08/09/2017
- • Available online on 23/09/2017
This article is available as full text PDF.
- Pathan, Arif H.K. [PubMed] [Google Scholar] 1
- Barash, Alexander [PubMed] [Google Scholar] 1, 3
- Tena, Lawrence B. [PubMed] [Google Scholar] 1, 2
- Finger, Paul T. [PubMed] [Google Scholar] 1, 2, 3, * Corresponding Author (firstname.lastname@example.org)
Department of Ophthalmology, Ocular Tumor Service, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York - USA
Departments of Ophthalmic and Radiation Oncology, The New York Eye Cancer Center, New York, New York - USA
Departments of Ophthalmology and Radiation Oncology, Mount Sinai Icahn School of Medicine, New York, New York - USA