To demonstrate the relationship between ischemia and plasma fibrinogen and serum albumin levels in cases of retinal vein occlusion (RVO).
This study included 44 patients with central RVO (CRVO), 68 patients with branch RVO (BRVO), and 54 age- and sex-matched controls, for a total of 166 subjects. All of the subjects underwent full ophthalmologic examinations and complete physical examinations, including a detailed medical history and blood count, and biochemical parameters.
The mean fibrinogen to albumin ratios were 92.5 ± 36.1 for the patients with CRVO, 84.5 ± 31.5 for the patients with BRVO, and 68.4 ± 12.2 for the control group. Overall, the patients with CRVO and patients with BRVO with ischemia had higher fibrinogen to albumin ratios and higher fibrinogen levels. Moreover, significant positive correlations were found between ischemia and the fibrinogen to albumin ratio (r = 0.732, p = 0.001) and the fibrinogen level (r = 0.669, p = 0.001).
The fibrinogen to albumin ratio is significantly associated with ischemic RVO. Instead of complicated and invasive methods, such as a retinal angiogram, the fibrinogen to albumin ratio could be a useful initial diagnostic test to predict ischemia in RVO.
Eur J Ophthalmol 2017; 27(6): 735 - 739
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsHande Guclu, Sadık A. Ozal, Vuslat Pelitli Gurlu, Gülben Sayılan Özgün, Eray Özgün
- • Accepted on 29/01/2017
- • Available online on 03/03/2017
- • Published in print on 08/11/2017
This article is available as full text PDF.
- Guclu, Hande [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Ozal, Sadık A. [PubMed] [Google Scholar] 1
- Pelitli Gurlu, Vuslat [PubMed] [Google Scholar] 1
- Özgün, Gülben Sayılan [PubMed] [Google Scholar] 2
- Özgün, Eray [PubMed] [Google Scholar] 2
Department of Ophthalmology, Trakya University, Faculty of Medicine, Edirne - Turkey
Department of Biochemistry, Trakya University, Faculty of Medicine, Edirne - Turkey