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Increased fibrinogen to albumin ratio in ischemic retinal vein occlusions

Abstract

Purpose

To demonstrate the relationship between ischemia and plasma fibrinogen and serum albumin levels in cases of retinal vein occlusion (RVO).

Methods

This study included 44 patients with central RVO (CRVO), 68 patients with branch RVO (BRVO), and 54 age- and sex-matched controls, for a total of 166 subjects. All of the subjects underwent full ophthalmologic examinations and complete physical examinations, including a detailed medical history and blood count, and biochemical parameters.

Results

The mean fibrinogen to albumin ratios were 92.5 ± 36.1 for the patients with CRVO, 84.5 ± 31.5 for the patients with BRVO, and 68.4 ± 12.2 for the control group. Overall, the patients with CRVO and patients with BRVO with ischemia had higher fibrinogen to albumin ratios and higher fibrinogen levels. Moreover, significant positive correlations were found between ischemia and the fibrinogen to albumin ratio (r = 0.732, p = 0.001) and the fibrinogen level (r = 0.669, p = 0.001).

Conclusions

The fibrinogen to albumin ratio is significantly associated with ischemic RVO. Instead of complicated and invasive methods, such as a retinal angiogram, the fibrinogen to albumin ratio could be a useful initial diagnostic test to predict ischemia in RVO.

Eur J Ophthalmol 2017; 27(6): 735 - 739

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ejo.5000942

Authors

Hande Guclu, Sadık A. Ozal, Vuslat Pelitli Gurlu, Gülben Sayılan Özgün, Eray Özgün

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  •  Department of Ophthalmology, Trakya University, Faculty of Medicine, Edirne - Turkey
  •  Department of Biochemistry, Trakya University, Faculty of Medicine, Edirne - Turkey

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