Peripapillary choroidal thickness by enhanced depth imaging optical coherence tomography: the impact of metabolic syndrome



To assess the impact of metabolic syndrome (MetS) on the peripapillary choroidal thickness (PPCT) and to characterize the PPCT in a Portuguese population.


This prospective study included 104 eyes. Detailed medical and ophthalmic examinations were performed; the PPCT was measured by spectral-domain optical coherence tomography (SD-OCT) using enhanced depth imaging (EDI) modality. The PPCT changes with MetS, as well as with other clinical and demographic factors, were investigated.


The mean PPCT was 142.4 ± 54.0 µm (58-303 µm); it was thickest superiorly, followed by the temporal, nasal, and inferior sectors. The PPCT was significantly associated with axial length (p<0.001), age (p = 0.001), intraocular pressure (IOP) (p = 0.041), weight (p = 0.015), and arterial hypertension (p = 0.044). The presence of MetS was associated with thinner PPCT in all sectors, being statistically significant in the temporal (p = 0.032) and inferotemporal (p = 0.034) sectors.


The choroidal thickness was significantly less in temporal and inferotemporal sectors in patients with MetS than in controls. This may suggest vascular insufficiency around the optic nerve head.

Eur J Ophthalmol 2017; 27(4): 428 - 432




Mónica Loureiro, Ana Cristina Braga, Dália Meira, Paula Sepúlveda, Luís Agrelos, Paulo Torres

Article History


Financial support: Partially supported by a grant of the Portuguese Society of Ophthalmology.
Conflict of interest: None of the authors has conflict of interest with this submission.

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  • Department of Ophthalmology, Centro Hospitalar de V. N. Gaia/Espinho, Vila Nova de Gaia - Portugal
  • Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto - Portugal
  • ALGORITMI Centre, University of Minho, Braga - Portugal
  • Department of Ophthalmology, Centro Hospitalar do Porto, Porto - Portugal

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