To evaluate the efficacy and safety of Ex-PRESS mini glaucoma shunt implantation with preoperative intracameral bevacizumab injection in eyes with refractory neovascular glaucoma.
A retrospective chart review of patients with medically uncontrolled neovascular glaucoma who had received 50-µL intracameral bevacizumab (1.25 mg) before undergoing Ex-PRESS mini glaucoma shunt implantation was performed. Success was defined as a postoperative intraocular pressure (IOP) between 5 and 21 mm Hg without (complete success) or with or without (qualified success) glaucoma medications and no additional glaucoma surgery, or loss of light perception.
In total, 33 eyes of 33 patients (15 female, 18 male) were enrolled in the study. The mean age of the study population was 61.2 years (range 36-78). The mean IOP decreased from 41.0 mm Hg (range 24-72) to 17.6 mm Hg (range 8-28) over a mean follow-up of 20.9 months (range 6-60) (p<0.001; Wilcoxon signed-rank test). Complete and qualified success rates were 36.4% and 66.7%, respectively. The average number of antiglaucoma medications decreased from 3.5 (range 2-4) preoperatively to 1.8 (range 1-4) postoperatively (p<0.001; Wilcoxon signed rank test). In 81.8% of cases, the decrease in IOP was 30% or more postoperatively.
Ex-PRESS mini glaucoma shunt implantation with preoperative bevacizumab injection may be an effective alternative procedure for refractory neovascular glaucoma.
Eur J Ophthalmol 2016; 26(6): 575 - 580
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsSuzan Guven Yilmaz, Seyda Yildirim, Cumali Degirmenci, Halil Ates
- • Accepted on 24/01/2016
- • Available online on 05/03/2016
- • Published in print on 04/11/2016
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- Guven Yilmaz, Suzan [PubMed] [Google Scholar] , * Corresponding Author (firstname.lastname@example.org)
- Yildirim, Seyda [PubMed] [Google Scholar]
- Degirmenci, Cumali [PubMed] [Google Scholar]
- Ates, Halil [PubMed] [Google Scholar]
Faculty of Medicine, Department of Ophthalmology, Ege University, Izmir - Turkey