Dry eye disease (DED) is a common condition causing substantial burden. A randomized, controlled, single-masked study was performed in 40 patients with mild to moderate DED to evaluate the efficacy and safety of a collyrium based on crosslinked hyaluronic acid (XLHA) with coenzyme Q10 (CoQ10).
Enrolled subjects were divided into 2 groups: group A, treated with XLHA + CoQ10; and group B, treated with hyaluronic acid (HA). Eyedrops were administered 4 times daily for 3 months. The Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), corneal and conjunctival staining, and meibomian gland assessment (MGD) were evaluated; furthermore, corneal aesthesiometry, in vivo corneal confocal microscopy, visual acuity, intraocular pressure (IOP), and fundus examination were performed.
At the end of treatment, OSDI score significantly decreased in groups A and B (p<0.01 and p<0.05, respectively); the decrease was significantly higher in group A. Corneal staining decreased in both groups, with lower scores in group A. The MGD was significantly ameliorated in group A patients. No differences were found for corneal aesthesiometry or TBUT. Epithelial cell reflectivity was significantly reduced only in group A. For keratocytes and stromal matrix parameters, there was a significant improvement in group A. No changes were found for visual acuity, IOP, or fundus examination.
The XLHA + CoQ10 treatment showed greater effectiveness in DED compared to HA alone, probably due to the longer permanency on ocular surface and the antioxidant activity of CoQ10. Therefore, XLHA + CoQ10 eyedrops could represent a new possibility in dry eye treatment.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
Article Subject: Cornea
AuthorsElisa I. Postorino, Laura Rania, Emanuela Aragona, Carmen Mannucci, Angela Alibrandi, Gioacchino Calapai, Domenico Puzzolo, Pasquale Aragona
- • Accepted on 26/06/2017
- • Available online on 02/08/2017
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- Postorino, Elisa I. [PubMed] [Google Scholar] 1
- Rania, Laura [PubMed] [Google Scholar] 1
- Aragona, Emanuela [PubMed] [Google Scholar] 1
- Mannucci, Carmen [PubMed] [Google Scholar] 2
- Alibrandi, Angela [PubMed] [Google Scholar] 3
- Calapai, Gioacchino [PubMed] [Google Scholar] 2
- Puzzolo, Domenico [PubMed] [Google Scholar] 2
- Aragona, Pasquale [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
Department of Biomedical Sciences, Regional Referral Centre for the Ocular Surface Diseases, University of Messina, Messina - Italy
Department of Biomedical Sciences, University of Messina, Messina - Italy
Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina - Italy