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Restoration of photoreceptors in eyes with diabetic macular edema

Abstract

Abstract Purpose

To show the prognostic value of foveal microstructures using optical coherence tomography (OCT) for the restoration of inner segment/outer segment (IS/OS) junction layer following resolution of diabetic macular edema (DME).

Methods

Forty-one eyes of 39 patients with IS/OS damage at the time of DME that showed complete resolution of DME were included. Eyes were divided into 2 groups based on the IS/OS integrity at final visit, when edema was completely resolved: always damage group (damage at baseline and at final visit) and initial damage group (damage only at baseline). The OCT characteristics including the extent of the IS/OS damage, central subfield thickness (CST), maximum retinal thickness (MRT), presence or absence of subretinal fluid, duration of diabetic retinopathy, and duration of DME were studied. The integrity of IS/OS was evaluated at baseline and at last follow-up as percentage (0%-100%).

Results

Forty-four percent of eyes (18 eyes) achieved complete restoration of IS/OS after resolution of DME. There was no significant difference in CST or MRT during DME between the 2 groups. The always damage group had more IS/OS damage at baseline visit (23.6% ± 6.4% vs 10.7% ± 3.4%, p = 0.043) with a longer duration of DME (p = 0.025). Despite a borderline significance in visual acuity between the 2 groups at baseline (p = 0.05), the always damage group ended up with worse vision at last follow-up (p<0.001).

Conclusions

Patients with shorter duration of DME and less baseline IS/OS damage were more likely to have intact (restored) IS/OS after resolution of DME.

Eur J Ophthalmol 2017; 27(5): 585 - 590

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ejo.5000907

Authors

Ilkay K. Muftuoglu, Erkan Unsal, Zeynep K. Ozturker

Article History

Disclosures

Financial support: I.K.M. received a grant from The Scientific and Technological Research Council of Turkey (TUBITAK). The funding organization had no role in the design or conduct of this research.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • Department of Ophthalmology, Jacobs Retina Center at the Shiley Eye Institute, University of California, San Diego, La Jolla, California - USA
  • Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul - Turkey

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