Restoration of photoreceptors in eyes with diabetic macular edema


Abstract Purpose

To show the prognostic value of foveal microstructures using optical coherence tomography (OCT) for the restoration of inner segment/outer segment (IS/OS) junction layer following resolution of diabetic macular edema (DME).


Forty-one eyes of 39 patients with IS/OS damage at the time of DME that showed complete resolution of DME were included. Eyes were divided into 2 groups based on the IS/OS integrity at final visit, when edema was completely resolved: always damage group (damage at baseline and at final visit) and initial damage group (damage only at baseline). The OCT characteristics including the extent of the IS/OS damage, central subfield thickness (CST), maximum retinal thickness (MRT), presence or absence of subretinal fluid, duration of diabetic retinopathy, and duration of DME were studied. The integrity of IS/OS was evaluated at baseline and at last follow-up as percentage (0%-100%).


Forty-four percent of eyes (18 eyes) achieved complete restoration of IS/OS after resolution of DME. There was no significant difference in CST or MRT during DME between the 2 groups. The always damage group had more IS/OS damage at baseline visit (23.6% ± 6.4% vs 10.7% ± 3.4%, p = 0.043) with a longer duration of DME (p = 0.025). Despite a borderline significance in visual acuity between the 2 groups at baseline (p = 0.05), the always damage group ended up with worse vision at last follow-up (p<0.001).


Patients with shorter duration of DME and less baseline IS/OS damage were more likely to have intact (restored) IS/OS after resolution of DME.

Eur J Ophthalmol 2017; 27(5): 585 - 590




Ilkay K. Muftuoglu, Erkan Unsal, Zeynep K. Ozturker

Article History


Financial support: I.K.M. received a grant from The Scientific and Technological Research Council of Turkey (TUBITAK). The funding organization had no role in the design or conduct of this research.
Conflict of interest: None of the authors has conflict of interest with this submission.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.



  • Department of Ophthalmology, Jacobs Retina Center at the Shiley Eye Institute, University of California, San Diego, La Jolla, California - USA
  • Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul - Turkey

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.