Comparison of eyedrop instillation technique with and without a delivery device in inexperienced patients



To compare the instillation of eyedrops with and without Xal-Ease® delivery device in inexperienced patients based on patient observation and answers to a questionnaire.


This prospective study included consecutive patients considered inexperienced in instilling eyedrops. After a short explanation about the methods, drop instillation technique was evaluated with and without the device. Subjects also completed a survey regarding drop administration and satisfaction. Successful instillation was defined as instilling a single drop in the eye without touching the eye with the bottle tip on the first attempt.


The overall rate of successful instillation (43%) was the same for both techniques (with or without the device). Without the device, the bottle tip touched the eye or periocular tissues in 8 eyes (35%) compared with 0 (0%) with the Xal-Ease® (p<0.01). The number of eyedrops dispensed was significantly higher with Xal-Ease® (1.4 ± 0.5 without the device versus 2.0 ± 1.1 with Xal-Ease®; p = 0.03). Using the Xal-Ease® device, 13 (57%) of the patients needed to make more than one attempt, versus 6 (26%) patients without the device (p = 0.04). Overall, 9 (39%) preferred traditional instillation and 14 (61%) preferred to use the device.


Xal-Ease® successfully decreased mechanical contact of the tip of the bottle. However, Xal-Ease® failed to help inexperienced subjects dispense fewer drops, or improve accuracy, suggesting that more training might be needed to achieve a good eyedrop administration technique with the device.

Eur J Ophthalmol 2016; 26(6): 594 - 597




Beatriz F. Gomes, Marília Lordello, Luiz F. Celli, Marcony R. Santhiago, Haroldo V. Moraes

Article History


Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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  •  Federal University of Rio de Janeiro, Rio de Janeiro - Brazil
  •  Federal Hospital of Bonsucesso, Rio de Janeiro - Brazil
  •  University of São Paulo, São Paulo - Brazil

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