To investigate the early neurodegenerative changes of inner retina and choroid in type 1 and type 2 diabetic patients without retinopathy and with early-stage retinopathy.
In this observational cross-sectional study, 90 right eyes of 90 naive type 1 and 2 diabetic patients without diabetic retinopathy (DR) and with mild to moderate nonproliferative DR (NPDR) were analyzed. Forty healthy eyes were included as controls. We used spectral-domain optical coherence tomography to evaluate the ganglion cell complex (GCC) thickness, the retinal nerve fiber layer (RNFL) thickness, the choroid thickness, and the central foveal thickness (CFT) of patients and controls.
Average GCC thickness turned out to be thinner in type 2 diabetic patients with no DR and with NPDR compared to controls (
Type 2 diabetic patients without retinopathy and with early-stage retinopathy have inferior thickness values of GCC and choroid compared to controls. Insulin resistance might be a possible adjunctive pathogenetic aspect of neurodegeneration.
Eur J Ophthalmol 2017; 27(3): 346 - 351
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsLuisa Pierro, Lorenzo Iuliano, Maria Vittoria Cicinelli, Giuseppe Casalino, Francesco Bandello
- • Accepted on 03/10/2016
- • Available online on 22/10/2016
- • Published in print on 11/05/2017
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- Pierro, Luisa [PubMed] [Google Scholar]
- Iuliano, Lorenzo [PubMed] [Google Scholar] , * Corresponding Author (firstname.lastname@example.org)
- Cicinelli, Maria Vittoria [PubMed] [Google Scholar]
- Casalino, Giuseppe [PubMed] [Google Scholar]
- Bandello, Francesco [PubMed] [Google Scholar]
Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan - Italy