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Evaluation of anterior segment parameters in patients with neurofibromatosis type 1

Abstract

Purpose

To evaluate anterior segment parameters in patients with neurofibromatosis type 1 (NF1) in comparison to healthy individuals.

Methods

A total of 34 eyes from 17 patients with NF1 and 34 eyes from 17 age- and sex-matched healthy individuals were included in this study. Each participant underwent a comprehensive ophthalmic assessment including best-corrected visual acuity, slit-lamp biomicroscopy, stereoscopic fundus examination, and intraocular pressure. Central corneal thickness, corneal volume, corneal curvatures (K1 and K2), anterior chamber depth, anterior chamber volume, iridocorneal angle, and pupil size values were measured by Pentacam Scheimpflug camera.

Results

The mean anterior chamber depth, iridocorneal angle, and anterior chamber volume measurements revealed significantly lower values when compared with the control group (p<0.001, p<0.001, and p = 0.041, respectively). However, the mean pupil size was significantly larger when compared with the control group (p = 0.008). Central corneal thickness, corneal volume, K1, and K2 values were similar between the study and control groups (p = 0.875, p = 0.549, p = 0.066, and p = 0.166, respectively).

Conclusions

Our results reveal that NF1 is associated with statistically significant alterations in anterior chamber depth, iridocorneal angle, anterior chamber volume, and pupil size in patients with NF1 when compared with healthy controls.

Eur J Ophthalmol 2016; 26(6): 564 - 567

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ejo.5000756

Authors

Necati Duru, Emre Göktaş, Ayşe Özköse, Zeynep Duru, Orhan Altunel, Mustafa Ataş, Emin Özlü

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  •  Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey
  •  Department of Dermatology, Kayseri Education and Research Hospital, Kayseri - Turkey

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