To evaluate anterior segment parameters in patients with neurofibromatosis type 1 (NF1) in comparison to healthy individuals.
A total of 34 eyes from 17 patients with NF1 and 34 eyes from 17 age- and sex-matched healthy individuals were included in this study. Each participant underwent a comprehensive ophthalmic assessment including best-corrected visual acuity, slit-lamp biomicroscopy, stereoscopic fundus examination, and intraocular pressure. Central corneal thickness, corneal volume, corneal curvatures (K1 and K2), anterior chamber depth, anterior chamber volume, iridocorneal angle, and pupil size values were measured by Pentacam Scheimpflug camera.
The mean anterior chamber depth, iridocorneal angle, and anterior chamber volume measurements revealed signiﬁcantly lower values when compared with the control group (p<0.001, p<0.001, and p = 0.041, respectively). However, the mean pupil size was significantly larger when compared with the control group (p = 0.008). Central corneal thickness, corneal volume, K1, and K2 values were similar between the study and control groups (p = 0.875, p = 0.549, p = 0.066, and p = 0.166, respectively).
Our results reveal that NF1 is associated with statistically signiﬁcant alterations in anterior chamber depth, iridocorneal angle, anterior chamber volume, and pupil size in patients with NF1 when compared with healthy controls.
Eur J Ophthalmol 2016; 26(6): 564 - 567
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsNecati Duru, Emre Göktaş, Ayşe Özköse, Zeynep Duru, Orhan Altunel, Mustafa Ataş, Emin Özlü
- • Accepted on 09/01/2016
- • Available online on 28/01/2016
- • Published in print on 04/11/2016
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- Duru, Necati [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Göktaş, Emre [PubMed] [Google Scholar] 1
- Özköse, Ayşe [PubMed] [Google Scholar] 1
- Duru, Zeynep [PubMed] [Google Scholar] 1
- Altunel, Orhan [PubMed] [Google Scholar] 1
- Ataş, Mustafa [PubMed] [Google Scholar] 1
- Özlü, Emin [PubMed] [Google Scholar] 2
Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey
Department of Dermatology, Kayseri Education and Research Hospital, Kayseri - Turkey