To assess retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and macular thickness changes in young adults with systemic arterial hypertension.
This study included 80 young patients (age 23.8 ± 2.8 years) with systemic hypertension (sHT) without any known systemic or ocular disease and 80 age-matched (23.5 ± 2.1 years) healthy controls. Retinal nerve fiber layer thickness, macular thickness, and GCC thickness were measured with spectral-domain optical coherence tomography.
Mean disease duration was 3.45 ± 1.48 years (range 2-10). Differences in intraocular pressure, body mass index, axial length, and spherical equivalent between the groups were insignificant (p>0.05). The differences in RNFL thickness did not differ between the groups. Patients with sHT had significantly lower central macular thickness (p = 0.037), inner superior macular thickness (p = 0.045), and outer temporal superior and outer temporal inferior GCC (p<0.001 for both). The RNFL thickness did not differ significantly in all quadrants between the groups (p>0.05). Systolic and diastolic blood pressure were significantly correlated with inner temporal superior and inner temporal inferior GCC thickness in a negative manner (p<0.05 for all).
Ganglion cell complex thickness decrease is possibly a better retinal marker for hypertensive changes with respect to RNFL and macular thickness.
Eur J Ophthalmol 2016; 26(5): 436 - 441
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsFahrettin Akay, Fatih C. Gündoğan, Umit Yolcu, Sami Toyran, Elif Tunç, Salih Uzun
- • Accepted on 26/01/2016
- • Available online on 26/02/2016
- • Published in print on 04/08/2016
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- Akay, Fahrettin [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Gündoğan, Fatih C. [PubMed] [Google Scholar] 2
- Yolcu, Umit [PubMed] [Google Scholar] 3
- Toyran, Sami [PubMed] [Google Scholar] 1
- Tunç, Elif [PubMed] [Google Scholar] 4
- Uzun, Salih [PubMed] [Google Scholar] 5
Department of Ophthalmology, Izmir Military Hospital, Izmir - Turkey
Department of Ophthalmology, GATA Medical School, Ankara - Turkey
Department of Ophthalmology, Ankara Mevki Military Hospital, Ankara - Turkey
Department of Cardiology, Izmir Military Hospital, Izmir - Turkey
Department of Ophthalmology, Etimesgut Military Hospital, Ankara - Turkey