To investigate the association between anterior lamina cribrosa depth (ALCD), determined with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), and intraocular pressure (IOP) in a healthy Portuguese population.
In this cross-sectional observational study conducted between January and July 2015, 2 optic nerve head (ONH)–centered EDI-OCT cross-scans were performed and ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch’s membrane opening and the anterior border of the lamina cribrosa at the maximum depth point. A multivariate regression model was performed to assess the association of IOP and ALCD.
The studied population included 59 subjects (35 women) with a mean age of 61.7 ± 15.1 years. Mean vertical and horizontal maximum ALCD was 444.5 ± 92.2 μm and 427.6 ± 82.7 μm, respectively. When controlling for age and spherical equivalent, maximum vertical and horizontal ALCD were positively correlated with intraocular pressure (R2>0.20) by 8.58 μm (95% confidence interval [CI] 2.80-14.36 μm; p<0.01) and 8.25 μm (95% CI 2.71-13.78 μm; p<0.01) per mm Hg of IOP, respectively.
Our sample of healthy subjects presented a statistically significant positive correlation between IOP and ALCD when controlling for possible confounding factors. These results may trigger further studies to better elucidate the role of IOP in the morphologic and functional dynamics of the ONH.
Eur J Ophthalmol 2017; 27(3): 295 - 300
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsDavid Cordeiro Sousa, Inês Leal, Carlos Marques-Neves, Filomena Pinto, Luís Abegão Pinto
- • Accepted on 18/08/2016
- • Available online on 13/09/2016
- • Published in print on 11/05/2017
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- Sousa, David Cordeiro [PubMed] [Google Scholar] 1, 2, 3, * Corresponding Author (email@example.com)
- Leal, Inês [PubMed] [Google Scholar] 1, 2, 3
- Marques-Neves, Carlos [PubMed] [Google Scholar] 1, 2, 3
- Pinto, Filomena [PubMed] [Google Scholar] 1, 2
- Abegão Pinto, Luís [PubMed] [Google Scholar] 1, 2, 3
Departamento de Oftalmologia, Hospital de Santa Maria, Lisboa - Portugal
Faculdade de Medicina, Universidade de Lisboa, Lisboa - Portugal
Centro de Estudos das Ciências da Visão, Lisboa - Portugal