Choroidal neovascularization in multifocal choroiditis after dabrafenib and trametinib



To describe a case of bilateral choroidal neovascularization (CNV) in multifocal choroiditis (MFC) associated with dabrafenib and trametinib chemotherapy for metastatic melanoma.


We present a case of a 57-year-old man with MFC who underwent combination therapy with dabrafenib plus trametinib for metastatic melanoma. The patient presented to our ophthalmology department complaining of bilateral vision loss of 2 days’ duration. He underwent multimodal imaging showing a MFC reactivation complicated by bilateral CNV. The patient underwent 3 ranibizumab injections in the right eye and 7 ranibizumab injections in the left eye. Anatomical and functional improvement has been observed.


This report emphasizes the importance of strict ophthalmologic follow-up in patients with metastatic melanoma treated with dabrafenib plus trametinib since rare severe ocular toxicities can occur, especially in patients with a history of uveitis.

Eur J Ophthalmol 2017; 27(6): e184 - e186

Article Type: CASE REPORT



Giorgia C. Albertini, Eleonora Corbelli, Maurizio Battaglia Parodi, Francesco Bandello

Article History


Financial support: No financial support was received for this submission.
Conflict of interest statement: None of the authors has conflict of interest with this submission.

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  • Department of Ophthalmology, Vita-Salute University, IRCCS Ospedale San Raffaele, Milan - Italy

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