To determine the effects of panretinal photocoagulation (PRP) on corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with unilateral central retinal vein occlusion (CRVO) who had previously undergone PRP treatment.
Sixty-four eyes of 32 patients (19 male, 13 female) with unilateral ischemic type CRVO who had undergone PRP treatment at least 6 months previously were included in this cross-sectional study. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the PRP-treated eyes were compared with those of the fellow unaffected eyes.
The mean age of patients was 63.5 ± 10.7 years (range 45-85 years). The mean nerve fiber density (NFD), nerve branch density, and nerve fiber length (NFL) were significantly lower in PRP-treated eyes compared with fellow eyes (p<0.001 for all). Average peripapillary RNFL thickness was significantly lower in PRP-treated eyes than in fellow eyes (p = 0.007). The NFD and NFL showed a modest but significant positive correlation with average peripapillary RNFL thickness (r = 0.310, p = 0.013 and r = 0.272, p = 0.030, respectively).
Significant reductions in corneal SBNP parameters and average peripapillary RNFL thickness were observed in the eyes of patients receiving PRP for the treatment of ischemic CRVO.
Eur J Ophthalmol 2017; 27(5): 591 - 595
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsGulfidan Bitirgen, Selman Belviranli, Rayaz A. Malik, Hurkan Kerimoglu, Ahmet Ozkagnici
- • Accepted on 28/12/2016
- • Available online on 23/01/2017
- • Published in print on 30/08/2017
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- Bitirgen, Gulfidan [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Belviranli, Selman [PubMed] [Google Scholar] 1
- Malik, Rayaz A. [PubMed] [Google Scholar] 2, 3
- Kerimoglu, Hurkan [PubMed] [Google Scholar] 1
- Ozkagnici, Ahmet [PubMed] [Google Scholar] 1
Department of Ophthalmology, Necmettin Erbakan University, Meram Faculty of Medicine, Konya - Turkey
Weill Cornell Medicine-Qatar, Education City, Doha - Qatar
Central Manchester University Teaching Hospitals, Foundation Trust and Division of Cardiovascular Sciences, University of Manchester, Manchester - UK