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Long-term results of pars plana vitrectomy as an anti-inflammatory therapy of pediatric intermediate uveitis resistant to standard medical treatment

Abstract

Purpose

To evaluate the efficacy of pars plana vitrectomy (PPV) as an anti-inflammatory therapy in pediatric recurrent intermediate uveitis.

Methods

A retrospective study evaluated the long-term results of PPV indicated for intermediate uveitis with a mean observation period of 10.3 years (range 7-15.6 years) in 6 children (mean age 8 years, range 6-12 years). Pars plana vitrectomy was performed on 10 eyes in the standard manner and was initiated by vitreous sampling for laboratory examination. Data recorded were perioperative or postoperative vitrectomy complications, anatomic and functional results of PPV, and preoperative and postoperative best-corrected Snellen visual acuity.

Results

No perioperative or postoperative complications were observed. Bacteriologic, virologic, mycotic, and cytologic analysis of the vitreous was negative in all tested children. Five eyes were subsequently operated on for posterior subcapsular cataracts. An average preoperative visual acuity of 0.32 improved to an average postoperative visual acuity of 0.8.

Conclusions

In the case of systemic immunosuppressive treatment failure in pediatric uveitis, particularly in eyes with cystoid macular edema, we recommend PPV relatively early.

Post author correction

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ejo.5001020

Authors

Denisa Darsová, Pavel Pochop, Jana Štěpánková, Dagmar Dotřelová

Article History

Disclosures

Financial support: Supported by Ministry of Health, Czech Republic - conceptual development of the research organization, Motol Univesity Hospital, Prague, Czech Republic 00064203.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • Department of Ophthalmology, Second Faculty of Medicine, Charles University Prague and Motol University Hospital, Prague - Czech Republic

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