To assess the etiology, clinical features, and outcome of choroidal neovascularization (CNV) in children.
We retrospectively assessed 10 eyes of 8 patients younger than 18 years diagnosed with CNV. The main clinical parameters included predisposing ocular pathologies, best-corrected visual acuity before and after treatment, characteristics of CNV, and treatment modalities.
Two boys and 6 girls with CNV and a mean age of 13.9 years (SD 1.9, range 11-16 years) were included. Two patients developed bilateral CNV within the follow-up time. The development of CNV was secondary to the following pathologies: choroidal osteoma (n = 3), pathologic myopia (n = 1), punctate inner choroidopathy (n = 1), hereditary macular dystrophy (n = 2), and angioid streaks (n = 1). Idiopathic CNV was diagnosed in 2 children without any obvious associated ocular pathology. In 9 eyes, CNV was treated by intravitreal anti–vascular endothelial growth factor (VEGF) administration (n = 6), photodynamic therapy (n = 1), or combination therapy (n = 3). One eye remained untreated because of advanced disease.
Pediatric CNV is a rare but sight-threatening retinal disease. So far, no standard treatment has been validated. Since the establishment of intravitreal anti-VEGF therapy, laser coagulation and photodynamic therapy have lost their significance as therapy for CNV.
Eur J Ophthalmol 2016; 26(5): 388 - 393
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsTeresa Barth, Florian Zeman, Horst Helbig, Isabel Oberacher-Velten
- • Accepted on 19/05/2016
- • Available online on 27/06/2016
- • Published in print on 04/08/2016
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- Barth, Teresa [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Zeman, Florian [PubMed] [Google Scholar] 2
- Helbig, Horst [PubMed] [Google Scholar] 1
- Oberacher-Velten, Isabel [PubMed] [Google Scholar] 1
Department of Ophthalmology, University Medical Centre Regensburg, Regensburg - Germany
Centre for Clinical Studies (ZKS), University Medical Centre Regensburg, Regensburg - Germany