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Etiology and treatment of choroidal neovascularization in pediatric patients

Abstract

Purpose

To assess the etiology, clinical features, and outcome of choroidal neovascularization (CNV) in children.

Methods

We retrospectively assessed 10 eyes of 8 patients younger than 18 years diagnosed with CNV. The main clinical parameters included predisposing ocular pathologies, best-corrected visual acuity before and after treatment, characteristics of CNV, and treatment modalities.

Results

Two boys and 6 girls with CNV and a mean age of 13.9 years (SD 1.9, range 11-16 years) were included. Two patients developed bilateral CNV within the follow-up time. The development of CNV was secondary to the following pathologies: choroidal osteoma (n = 3), pathologic myopia (n = 1), punctate inner choroidopathy (n = 1), hereditary macular dystrophy (n = 2), and angioid streaks (n = 1). Idiopathic CNV was diagnosed in 2 children without any obvious associated ocular pathology. In 9 eyes, CNV was treated by intravitreal anti–vascular endothelial growth factor (VEGF) administration (n = 6), photodynamic therapy (n = 1), or combination therapy (n = 3). One eye remained untreated because of advanced disease.

Conclusions

Pediatric CNV is a rare but sight-threatening retinal disease. So far, no standard treatment has been validated. Since the establishment of intravitreal anti-VEGF therapy, laser coagulation and photodynamic therapy have lost their significance as therapy for CNV.

Eur J Ophthalmol 2016; 26(5): 388 - 393

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ejo.5000820

Authors

Teresa Barth, Florian Zeman, Horst Helbig, Isabel Oberacher-Velten

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • Department of Ophthalmology, University Medical Centre Regensburg, Regensburg - Germany
  • Centre for Clinical Studies (ZKS), University Medical Centre Regensburg, Regensburg - Germany

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