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Rod function in diabetic patients without and with early diabetic retinopathy

Abstract

Purpose

To compare rod function among diabetic patients without and with mild nonproliferative diabetic retinopathy (DR) and healthy controls by means of scotopic microperimetry and dark-adapted electroretinography.

Methods

Sixty-one diabetic patients and 30 age-matched controls (control group) underwent complete ophthalmic examination, scotopic microperimetry, and dark-adapted 0.01 electroretinography (DA-ERG).

Results

In 32 eyes, DR was absent (no-DR group); in 29 eyes, only microaneurysms were observed (DR group). No statistically significant differences in fixation stability, fixation location, or scotopic sensitivity among the 3 groups were observed. Implicit time and amplitude of the DA-ERG b-wave of no-DR and DR groups were not different from controls. Scotopic microperimetry showed a dense scotoma centered onto the fovea in all subjects, consistent with the rod-free zone. Greater scotopic sensitivity was found in a ring located 8° from the fovea (9.33 ± 1.33 dB).

Conclusions

Diabetic patients without DR and with mild nonproliferative DR did not show alterations in rod-based function, as examined by microperimetry and confirmed by DA-ERG. Scotopic microperimetry measures rod-based function and offers additional information in the evaluation of the aspects of involvement of retinal cells in diabetes.

Eur J Ophthalmol 2016; 26(5): 418 - 424

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ejo.5000800

Authors

Evelyn Longhin, Alma P. Tormene, Elena Olivato, Enrica Convento, Stela Vujosevic, Elisabetta Pilotto, Olympia Kotsafti, Edoardo Midena

Article History

Disclosures

Financial support: This study was supported by a grant from the 7th Framework Programme (EUROCONDOR. FP7-278040). The scientific contribution by G.B. Bietti Foundation researchers was supported by Fondazione Roma and the Italian Ministry of Health.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  •  Department of Ophthalmology, University of Padua, Padua - Italy
  •  G.B. Bietti Foundation, IRCCS, Rome - Italy

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