To compare rod function among diabetic patients without and with mild nonproliferative diabetic retinopathy (DR) and healthy controls by means of scotopic microperimetry and dark-adapted electroretinography.
Sixty-one diabetic patients and 30 age-matched controls (control group) underwent complete ophthalmic examination, scotopic microperimetry, and dark-adapted 0.01 electroretinography (DA-ERG).
In 32 eyes, DR was absent (no-DR group); in 29 eyes, only microaneurysms were observed (DR group). No statistically significant differences in fixation stability, fixation location, or scotopic sensitivity among the 3 groups were observed. Implicit time and amplitude of the DA-ERG b-wave of no-DR and DR groups were not different from controls. Scotopic microperimetry showed a dense scotoma centered onto the fovea in all subjects, consistent with the rod-free zone. Greater scotopic sensitivity was found in a ring located 8° from the fovea (9.33 ± 1.33 dB).
Diabetic patients without DR and with mild nonproliferative DR did not show alterations in rod-based function, as examined by microperimetry and confirmed by DA-ERG. Scotopic microperimetry measures rod-based function and offers additional information in the evaluation of the aspects of involvement of retinal cells in diabetes.
Eur J Ophthalmol 2016; 26(5): 418 - 424
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsEvelyn Longhin, Alma P. Tormene, Elena Olivato, Enrica Convento, Stela Vujosevic, Elisabetta Pilotto, Olympia Kotsafti, Edoardo Midena
- • Accepted on 07/04/2016
- • Available online on 13/05/2016
- • Published in print on 04/08/2016
This article is available as full text PDF.
- Longhin, Evelyn [PubMed] [Google Scholar] 1
- Tormene, Alma P. [PubMed] [Google Scholar] 1
- Olivato, Elena [PubMed] [Google Scholar] 1
- Convento, Enrica [PubMed] [Google Scholar] 1
- Vujosevic, Stela [PubMed] [Google Scholar] 1
- Pilotto, Elisabetta [PubMed] [Google Scholar] 1
- Kotsafti, Olympia [PubMed] [Google Scholar] 2
- Midena, Edoardo [PubMed] [Google Scholar] 1, 2, * Corresponding Author (email@example.com)
Department of Ophthalmology, University of Padua, Padua - Italy
G.B. Bietti Foundation, IRCCS, Rome - Italy