To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings.
The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by ﬂow cytometry. Demographic and clinical data were recorded.
The mean ages of patients in the study and control groups were 71 ± 8 and 68 ± 6 years, respectively. There was no statistically significant difference in terms of age, sex, or systemic disease association between study and control groups. However, smoking status was significantly higher in the study group (67.9% vs 37.0%; p = 0.02). Stem cell levels were significantly higher in the study group (1.5 ± 0.9 vs 0.5 ± 0.3; p<0.001), but there was no relation between stem cell levels and clinical and OCT findings.
Increased circulating CD34+ stem cell levels were observed in patients with choroidal neovascular membrane associated with AMD, but no significant relation was found between cell levels and clinical and OCT findings.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
Article Subject: Retina MED
AuthorsCaner Kara, Pınar Ç. Özdal, Emrullah Beyazyıldız, Nurgül E. Özcan, Mehmet Y. Teke, Gülden Vural, Faruk Öztürk
- • Accepted on 28/06/2017
- • Available online on 02/08/2017
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- Kara, Caner [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Ç. Özdal, Pınar [PubMed] [Google Scholar] 2
- Beyazyıldız, Emrullah [PubMed] [Google Scholar] 3
- E. Özcan, Nurgül [PubMed] [Google Scholar] 4
- Y. Teke, Mehmet [PubMed] [Google Scholar] 2
- Vural, Gülden [PubMed] [Google Scholar] 5
- Öztürk, Faruk [PubMed] [Google Scholar] 6
Department of Ophthalmology, Etlik Zübeyde Hanim Women’s Health Education and Research Hospital, Ankara - Turkey
Department of Retina and Vitreous Diseases, Ulucanlar Eye Research and Training Hospital, Ankara - Turkey
Department of Ophthalmology, Samsun Training and Research Hospital, Samsun - Turkey
Department of Biochemistry, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara - Turkey
Department of Hematology, Faculty of Medicine, Gazi University, Ankara - Turkey
Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara - Turkey