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Increased levels of circulating CD34+ cells in neovascular age-related macular degeneration: relation with clinical and OCT features

Abstract

Purpose

To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings.

Methods

The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by flow cytometry. Demographic and clinical data were recorded.

Results

The mean ages of patients in the study and control groups were 71 ± 8 and 68 ± 6 years, respectively. There was no statistically significant difference in terms of age, sex, or systemic disease association between study and control groups. However, smoking status was significantly higher in the study group (67.9% vs 37.0%; p = 0.02). Stem cell levels were significantly higher in the study group (1.5 ± 0.9 vs 0.5 ± 0.3; p<0.001), but there was no relation between stem cell levels and clinical and OCT findings.

Conclusions

Increased circulating CD34+ stem cell levels were observed in patients with choroidal neovascular membrane associated with AMD, but no significant relation was found between cell levels and clinical and OCT findings.

Post author correction

Article Type: ORIGINAL RESEARCH ARTICLE

Article Subject: Retina MED

DOI:10.5301/ejo.5001012

Authors

Caner Kara, Pınar Ç. Özdal, Emrullah Beyazyıldız, Nurgül E. Özcan, Mehmet Y. Teke, Gülden Vural, Faruk Öztürk

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  •  Department of Ophthalmology, Etlik Zübeyde Hanim Women’s Health Education and Research Hospital, Ankara - Turkey
  •  Department of Retina and Vitreous Diseases, Ulucanlar Eye Research and Training Hospital, Ankara - Turkey
  •  Department of Ophthalmology, Samsun Training and Research Hospital, Samsun - Turkey
  •  Department of Biochemistry, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara - Turkey
  •  Department of Hematology, Faculty of Medicine, Gazi University, Ankara - Turkey
  •  Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara - Turkey

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