Pegaptanib: choroidal neovascularization in patients with age-related macular degeneration and previous arterial thromboembolic events



To evaluate the efficacy and the rate of side effects of the pegylated aptamer pegaptanib in the treatment of patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and a history of previous arterial thromboembolic events (ATEs).


Twenty-three eyes of 23 patients with subfoveal CNV due to AMD and cerebrovascular accidents (n = 12) and myocardial infarction (n = 11) in the previous 6 months received intravitreal pegaptanib 0.3 mg according to a pro re nata regimen and were followed for 12 months. The paired Student t test was used to evaluate mean changes in best-corrected visual acuity (BCVA; primary outcome measure) and central foveal thickness (CFT).


The mean patient age was 71.5 ± 4.6 years; there were 14 women and 9 men. The CNV was type 1, 2, and 3 in 18, 3, and 2 eyes, respectively. The mean BCVA improved from 0.67 ± 0.23 logMAR at baseline to 0.52 ± 0.31 logMAR at the end of 12-month follow-up (p = 0.044). Thirty-five percent of patients achieved ≥3 Early Treatment Diabetic Retinopathy Study lines improvement at 12 months. Mean CFT at baseline (381 ± 111 µm) decreased to 304 ± 82 µm at 12 months (p = 0.008). Patients received a mean of 4.3 ± 1.3 (range 3-7) injections. No systemic or ocular side effects occurred; no patient experienced further ATEs.


Intravitreal pegaptanib can be considered a viable treatment option for patients with AMD-related CNV who are at high risk of ATEs.

Post author correction


Article Subject: Retina MED



Maurizio Battaglia Parodi, Emanuele Di Bartolo, Claudia Brue, Ezio Cappello, Claudio Furino, Sebastiano Giuffrida, Manuela Imparato, Michele Reibaldi

Article History


Financial support: No financial support was received for this submission.
Conflict of interest: M.B.P. is a consultant for Bausch & Lomb. None of the other authors has conflict of interest with this submission.

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  •  Department of Ophthalmology, Ospedale San Raffaele, Milan - Italy
  •  Department of Ophthalmology, Azienda Ospedaliero-Universitaria Pisana, Pisa - Italy
  •  Department of Ophthalmology, Polytechnic University of Marche, Ancona - Italy
  •  Department of Ophthalmology, Ospedale San Bassiano, Bassano del Grappa - Italy
  •  Department of Ophthalmology, University of Bari, Bari - Italy
  •  Bausch and Lomb Iom SpA, Vimodrone, Milan - Italy
  •  Department of Ophthalmology, Fondazione IRCCS Policlinico San Matteo, Pavia - Italy
  •  Department of Ophthalmology, University of Catania, Catania - Italy

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